Endocrine Abstracts

Introduction: In treating hyperthyroidism in Graves’ disease (GD) patients with 131-iodine, the optimum activity of radioiodide is yet to be established. We analysed factors affecting the efficacy of 131I radiotherapy in GD patients.Materials and methods: The analysed group consisted of 362 (80.9% females and 19.1% males) GD patients, of median age 53 (min: 14 and max: 85) years. GD was diagnosed from clinical features, laboratory tests, ...

Germline AIP gene mutations have been linked with familial isolated pituitary adenomas (FIPA). Inactivating mutations of AIP have also been reported in seemingly sporadic pituitary adenomas, particularly of early onset, aggressive, and GH secreting.Aim: To assess the frequency and type of germline AIP gene mutations in patients with apparently sporadic PMAs.Material: The study included 31 consecutive patients with pituitary macroad...

Differentiated thyroid cancer (DTC) is a relatively mild disease if detected early.The aim of the study was ultrasound evaluation of thyroid gland, selection of thyroid nodules with high chances of malignancy, and their verification in fine-needle aspiration (FNA), as well as assessment of TSH concentration and antiTPO titre.The study involved 100 patients. DTC was diagnosed in 14 patients and undifferentiated or medullary thyroid ...

Introduction: Acromegaly is a rare disorder caused by excessive growth hormone production. Common clinical manifestations are visual changes as well as serious systemic complications. In childhood and adolescence, excessive growth hormone production leads to abnormal tall stature. To date, only a few studies have been published focusing on analysing the growth of patients with acromegaly, in particular regarding the growth of their parents and siblings. A&#...

Up to 5% of all pituitary tumors are hereditary (e.g. due to menin or AIP genes mutations). AIP gene mutations are more common in subjects with acromegaly, less than 30 years old at the onset of disease, and with FIPA family history. The study was aimed at the assessment of the frequency and characteristics of AIP-mutation related tumors in non-selected patients with pituitary macroadenomas.Material and Methods: The study included subsequent 131 patients...

The prevalence of adrenal incidentalomas in computed tomography (CT) studies ranges from 0.6–1.9%. Adrenal masses are detected bilaterally in 10–15% of the cases.Non-classic adrenal hyperplasia (NCAH), also termed as late onset of CAH, is a very mild form of 21-hydroxylase deficiency. The incidence of disease is estimated at 0.1% of population. Reported prevalence in women with androgen excess range from 0.6 to 9%.Some pa...

Objective: To determine the progression rate to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes (DM2) and risk factors of progression to diabetes in normal glucose tolerant (NGT) people during 8 years follow up study using WHO 1999 criteria and new criteria of IFG (IFG 5.6-fasting glucose 5.6–6.9 mmol/l).Research design and methods: This is an 8 year prospective observation in a randomly selected urban population aged ...

Multiple endocrine neoplasia type 1 is an inherited syndrome that is caused by a germline mutation in the MEN1 gene encoding a tumour-suppressor protein, menin. Currently, no clear genotype–phenotype correlation has been established between clinical forms and MEN1 gene mutations. The aim of the study was clinical characteristics in relation to MEN1 gene mutation in families with MEN1 syndrome treated in our department. To date, genetic testing including complete sequencin...

Introduction: During clinical observation the behaviour of pituitary tumours is often unpredictable. The work was aimed at evaluating Ki-67 and pituitary tumour transforming gene (PTTG) indices in pituitary adenomas.Material and methods: The Ki-67 and PTTG indices were determined by immunochemistry in specimens excised from neurosurgically removed pituitary tumours. In fifty two examined patients (30 females and 22 males, mean age 50.5±15.4 years) w...

Type 1 deiodinase (D1) catalyses deiodination of tyroxine (T4), which leads either to synthesis of triiodothyronine or reverse triiodothyronine (rT3). Triiodothyronine (T3) regulates the expression of many tumour suppressor genes and oncogenes. We previously revealed that the expression of the whole pool of D1 transcripts was dramatically lowered in ccRCC tissues. One of the mechanism resulting in this aberration could be miRNA-mediated repress...